Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypothalamic activation in spontaneous migraine attacks.

Marie Denuelle1, Nelly Fabre, Pierre Payoux

  • 1Neurology Service, Rangueil Hospital, Toulouse Cedex 9, France.

Headache
|December 7, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cortical gray-white matter contrast alterations precede amyloid-β positivity and macrostructural changes in older adults without dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Tics severity in Tourette syndrome associated with higher glutamatergic activity in the anterior cingulate cortex.

Brain communications·2026
Same author

A learning-evoked slow-oscillatory architecture paces population activity for offline reactivation across the human medial temporal lobe.

Neuron·2026
Same author

Did the French pregnancy pictogram change antiseizure medication use during pregnancy?

Epilepsia·2026
Same author

Refining Detection of Subclinical Epileptiform Activity in Alzheimer's Disease: A Case-Control Study and Call for a Consensus.

Annals of neurology·2026
Same author

Oxytocin in infants with Prader-Willi syndrome to improve dysphagia and disease trajectory.

Orphanet journal of rare diseases·2026
Same journal

Biochemical profiling and symptomatology of androgen deficiency in males with cluster headache: A prospective case-control study.

Headache·2026
Same journal

Thiamine deficiency in patients with chronic migraine: A case-control study.

Headache·2026
Same journal

Potential association of cluster headache with certain COVID-19 vaccines: An assessment from the pharmacovigilance databases.

Headache·2026
Same journal

Potential role of tirzepatide, a dual GLP-1 and GIP receptor agonist, for preventive treatment of migraine: A case series.

Headache·2026
Same journal

Adverse childhood experiences, migraine, and adverse pregnancy outcomes among teenage mothers.

Headache·2026
Same journal

Weight loss with atogepant in the long-term treatment of migraine: An interim analysis of a safety endpoint from a phase 3, multicenter, open-label, 156-week extension study.

Headache·2026
See all related articles

This study shows that the hypothalamus is activated during migraine attacks, a finding supported by brain imaging. This hypothalamic activity is linked to migraine triggers and persists even after pain relief.

Area of Science:

  • Neuroscience
  • Medical Imaging

Background:

  • Migraine attacks are preceded by symptoms suggesting hypothalamic dysfunction.
  • Previous brain imaging studies showed brainstem activation but not hypothalamic activation in migraineurs.

Purpose of the Study:

  • To investigate cerebral activations during spontaneous migraine without aura attacks using H2 15O PET scans.

Main Methods:

  • Positron emission tomography (PET) scans were performed on 7 migraine patients.
  • Scans were conducted during headache onset, after sumatriptan treatment, and during attack-free periods.

Main Results:

  • Significant activations were observed in the midbrain, pons, and hypothalamus during migraine headaches.
  • These hypothalamic activations persisted even after headache relief induced by sumatriptan.

Related Experiment Videos

Conclusions:

  • This study provides the first direct evidence of hypothalamic activity during spontaneous migraine attacks.
  • Hypothalamic activation is demonstrated as a key factor in migraine pathophysiology.