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Updated: Jul 9, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Diffusion MRI during migraine with aura attack associated with diagnostic microbubbles injection in subjects with
Lavinia Dinia1, Luca Roccatagliata, Laura Bonzano
1Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Italy.
Abstract:
The relationship between migraine with aura and patent foramen ovale (PFO) is still debatable. We report 2 cases of migraine with aura attacks after diagnostic microbubble injection for contrast transcranial Doppler (cTCD), in subjects with large PFO. In one case MR images, including diffusion weighted imaging and apparent diffusion coefficient, performed during aura did not show any signal abnormality. Patients with migraine with aura may have an attack during cTCD, probably by a "non-ischemic" mechanism.

