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Updated: Jul 9, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Tumors: too sweet to remember?
H Peter Vollmers1, Stephanie Brändlein
1Institute of Pathology, University of Würzburg, Josef-Schneider-Str, 2, D-97080 Würzburg, Germany. peter.vollmers@mail.uni-wuerzburg.de
Abstract:
Immunity, based on a natural and an educated system, is responsible for recognition and elimination of infectious particles, cellular waste, modified self and transformed cells. This dual system guarantees that dangerous particles are removed immediately after appearance and that a memory with maturated weapons exists, if the organism is re-infected by the same particle. For malignant cells, however, the immune response seems to be restricted to innate immunity, because at least for the humoral response, all so far detected tumor-specific antibodies belong to the natural immunity. In this review we try to explain why malignant cells might be "too sweet" to induce a memory.
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