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Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
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Regulation of vascular smooth muscle cell growth by survivin

Andrew W Hoel1, Grace J Wang, Hector F Simosa

  • 1Division of Vascular Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA.

Vascular
|December 7, 2007
PubMed

Insights

Survivin, an inhibitor of apoptosis protein, plays a key role in vascular smooth muscle cell growth. Inhibiting survivin may prevent restenosis after revascularization procedures.

Area of Science:

  • Cardiovascular Biology
  • Molecular Oncology

Background:

  • Survivin is an inhibitor of apoptosis protein implicated in cancer.
  • Survivin is increasingly recognized for its role in vascular injury pathways.
  • Vascular smooth muscle cell hyperplasia, driven by survivin, contributes to graft failure and restenosis.

Purpose of the Study:

  • To review the role of survivin in vascular smooth muscle cell growth.
  • To discuss survivin's implications for preventing restenosis after revascularization.
  • To summarize current knowledge on survivin expression, regulation, function, and inhibition.

Main Methods:

  • Literature review focusing on survivin in vascular biology.
  • Analysis of survivin's role in smooth muscle cell proliferation.
  • Examination of in vitro and in vivo studies on survivin inhibition.

Main Results:

  • Survivin regulates vascular smooth muscle cell growth.
  • Survivin is a key factor in neointimal lesion formation.
  • Inhibition of survivin shows potential in preclinical models.

Conclusions:

  • Survivin is a critical regulator of smooth muscle cell proliferation.
  • Targeting survivin offers a promising strategy for preventing restenosis.
  • Further research into survivin inhibition is warranted for vascular interventions.

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