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Related Experiment Video

Updated: Jul 9, 2026

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

Published on: May 4, 2021

[Agreement between two devices for measuring exhaled nitric oxide].

O Sardón Prado¹, A Aldasoro Ruiz, J Korta Murua

¹Unidad de Neumología Infantil, Servicio de Pediatría, Hospital de Donostia, San Sebastián, Spain. osardon@euskalnet.net

Anales De Pediatria (Barcelona, Spain : 2003)

|December 7, 2007

Summary

A new portable device for measuring fractional exhaled nitric oxide (FENO) shows good agreement with a standard analyzer. This portable FENO measurement is valid and feasible for children over 5 years old.

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Fast and Accurate Exhaled Breath Ammonia Measurement

Fast and Accurate Exhaled Breath Ammonia Measurement

Published on: June 11, 2014

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Last Updated: Jul 9, 2026

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

Published on: May 4, 2021

Fast and Accurate Exhaled Breath Ammonia Measurement

Fast and Accurate Exhaled Breath Ammonia Measurement

Published on: June 11, 2014

Area of Science:

Pulmonology
Medical Devices
Biomedical Engineering

Background:

Fractional exhaled nitric oxide (FENO) is a key non-invasive biomarker for eosinophilic airway inflammation.
FENO measurements aid in asthma diagnosis, control, and treatment monitoring.

Purpose of the Study:

To evaluate the correlation between a chemiluminescence-based FENO analyzer (NIOX) and a new portable electrochemical sensor-based analyzer (NIOX-MINO).
To assess the agreement and validity of the NIOX-MINO device for FENO measurement in children.

Main Methods:

FENO was measured using the single breath on-line method in 30 children.
Measurements were taken with both NIOX (mean of three readings) and NIOX-MINO (single reading).
Statistical analysis included Bland-Altman plots and Cohen's Kappa statistic to compare agreement.

Main Results:

A statistically significant relationship was found between FENO values from NIOX-MINO and NIOX (p<0.005).
Cohen's Kappa statistic of 0.78 indicated a high degree of agreement between the two devices.
All 30 children successfully completed measurements using both analyzers.

Conclusions:

The NIOX-MINO and NIOX analyzers are not equivalent but show good agreement for FENO measurement.
The portable NIOX-MINO device is a valid and feasible tool for measuring FENO in children aged 5 years and older.