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[Sleep apnea-hypopnea syndrome in a pediatric population: differences between children with tonsillar hypertrophy and
Mónica Llombart1, Eusebi Chiner, Elia Gómez-Merino
1Unidad de Trastornos de Sueño, Sección de Neumología, Hospital Universitari Sant Joan d'Alacant, San Juan de Alicante, Alicante, Spain. llombart_mon@gva.es
Insights
Pediatric sleep apnea-hypopnea syndrome (SAHS) patients with tonsillar hypertrophy showed better outcomes than those with concomitant disease. While both groups required interventions like surgery or positive airway pressure (PAP) therapy, healthy children experienced a more favorable clinical and polysomnographic evolution.
Area of Science:
- Pediatric Pulmonology
- Sleep Medicine
- Otolaryngology
Background:
- Sleep apnea-hypopnea syndrome (SAHS) in children often stems from tonsillar hypertrophy.
- Understanding clinical and polysomnographic differences is crucial for effective management.
- Concomitant diseases can influence SAHS presentation and treatment outcomes.
Purpose of the Study:
- To compare clinical and polysomnographic variables in pediatric SAHS patients with tonsillar hypertrophy versus those with concomitant disease.
- To identify specific characteristics associated with each group.
- To evaluate treatment outcomes and evolution in both patient cohorts.
Main Methods:
- A study involving 42 children diagnosed with SAHS.
- Patients were divided into two groups: 26 otherwise healthy (Group A) and 16 with concomitant disease (Group B).
- Clinical data, polysomnography, and treatment responses were analyzed and compared between groups.
Main Results:
- Group A (tonsillar hypertrophy) showed more frequent tonsillar hypertrophy (P=.02) and better outcomes, including higher oxygen saturation (P<.007) and lower desaturation index (P=.007).
- Group B (concomitant disease) had more craniofacial abnormalities (P=.008), macroglossia (P=.04), and dolichocephalia (P=.04), with greater nocturnal hypoventilation (P=.01).
- Group A underwent more tonsillectomies (88.5% vs 44%, P=.003), while Group B required more positive airway pressure (PAP) therapy (CPAP/BiPAP) and maxillary surgery.
Conclusions:
- Children with SAHS and concomitant disease tend to be more obese, have craniofacial abnormalities, and experience greater nocturnal hypoventilation.
- While most pediatric SAHS patients require interventions like surgery or PAP therapy, those with isolated tonsillar hypertrophy show a more favorable clinical and polysomnographic evolution.
- SAHS management should consider the presence of concomitant diseases, which may necessitate different therapeutic approaches and influence prognosis.
Objective:
Our aim was to compare clinical and polysomnographic variables in pediatric patients with sleep apnea-hypopnea syndrome (SAHS) secondary to tonsillar hypertrophy with those in patients with concomitant disease.
Patients And Methods:
We studied 42 children with SAHS (mean [SD] age, 8 [4] years; body mass index [BMI], 19.6 [5.2] kg/m2; neck circumference, 29 [4] cm; and BMI percentile, 67 [36]), 26 of whom were otherwise healthy (group A) and 16 of whom had concomitant disease (group B).
Results:
A comparison of groups A and B showed no significant differences in age (7.7 [3.9] years vs 8.4 [3.9] years; P=not significant [NS]); sex, BMI (17.6 [4] kg/m2 vs 20.4 [6] kg/m2; P=NS), neck circumference (29.3 [4.7] cm vs 30.7 [3.5] cm; P=NS), or BMI percentile (61 [37] vs 76 [34]; P=NS). Tonsillar hypertrophy was more frequent in group A (P=.02) and craniofacial abnormalities (P=.008), macroglossia (P=.04), and dolichocephalia (P=.04) were more frequent in group B. No significant differences were observed in neurophysiologic variables or in the respiratory disturbance index, although group A presented higher oxygen saturation levels (97 [1.7] vs 95 [2]; P< .007), lower oxygen desaturation index scores (7 [7] vs 15 [10]; P=.007), and a lower cumulative percentage of time with oxygen saturation lower than 90% (2.2 [4] vs 16.4 [4]; P=.01). Twenty-three patients (88.5%) in group A underwent tonsillectomies compared to 7 (44%) patients in group B (P=.003). Seven patients (44%) in group B were treated with continuous positive airway pressure (CPAP) and 2 patients were treated with bi-level positive airway pressure (BiPAP), compared to 1 patient (3.8%) treated with CPAP in group A (P=.003). Three children in group B underwent maxillary surgery. The evolution of clinical and polygraphic variables was more favorable in group A (P=.04).
Conclusions:
Children with SAHS suffer from repeated infections, delayed weight gain, hyperactivity, and neuropsychiatric manifestations. Obesity (associated with concomitant disease) and sleepiness are uncommon. Although most patients require surgery, as many as a third require treatment with CPAP or BiPAP. Furthermore, children with SAHS and concomitant disease show no specific clinical characteristics, although they tend to be more obese, have more craniofacial abnormalities, and greater nocturnal hypoventilation.
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