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Two types of thought disorder and lateralized neuropsychological dysfunction
M L Silverstein1, J T Marengo, L Fogg
1Dept. of Psychology, Long Island University, Brookville 11548.
Schizophrenia Bulletin
|January 1, 1991
Summary
Positive thought disorder in schizophrenia is linked to left-hemisphere brain function, while negative thought disorder shows diffuse or bilateral impairment. Medication status significantly influences these neuropsychological findings.
Area of Science:
- Neuropsychology
- Psychiatry
- Cognitive Neuroscience
Background:
- Thought disorder is a key symptom in functional psychoses.
- Cerebral lateralization and medication effects are potential modulators of thought disorder.
Purpose of the Study:
- To investigate the relationship between positive and negative thought disorder and cerebral lateralization.
- To examine the influence of psychotropic medication status on these relationships.
Main Methods:
- Utilized Halstead-Reitan Neuropsychological Battery and Wechsler Adult Intelligence Scale.
- Employed discriminant function analyses with left- and right-hemisphere variables.
- Included medication status as a key analytical variable.
Main Results:
- Positive thought disorder correlated with left-hemisphere neuropsychological variables.
- Negative thought disorder showed relationships with both left- and right-hemisphere variables.
- Verbal/performance IQ and medication status influenced negative thought disorder relationships.
Conclusions:
- Findings offer qualified support for left-hemisphere dysfunction in positive thought disorder.
- Negative thought disorder appears associated with diffuse or bilateral cerebral impairment.
- Medication status plays a significant role in the neuropsychological correlates of negative thought disorder.