Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Information Processing Approach01:30

Information Processing Approach

The information-processing theory of cognitive development centers on fundamental mental processes, including attention, memory, and problem-solving skills. Researchers in this field examine how cognitive abilities, such as working memory, evolve and influence children's overall development. Studies indicate that children with stronger working memory tend to excel in reading comprehension, math, and problem-solving compared to peers with less efficient memory skills. Low working memory is also...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rapid Onset of Pulmonary Arterial Hypertension After Liver Transplant-A Case Report.

Reports (MDPI)·2026
Same author

International Liver Transplantation Society/Liver Intensive Care Group of Europe guidelines for cardiovascular assessment before liver transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2025
Same author

Comprehensive analysis of ordering in CoCrNi and CrNi<sub>2</sub> alloys.

Nature communications·2024
Same author

A far-ultraviolet-driven photoevaporation flow observed in a protoplanetary disk.

Science (New York, N.Y.)·2024
Same author

On the origin of diffuse intensities in fcc electron diffraction patterns.

Nature·2023
Same author

Perioperative management of living donor liver transplantation: Part 2 - Donors.

Clinical transplantation·2022

Related Experiment Video

Updated: Jul 9, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Relationships between information processing, depression, fatigue and cognition in multiple sclerosis.

Bruce J Diamond1, Susan K Johnson, Michael Kaufman

  • 1William Paterson University, United States; University of North Carolina - Charlotte, United States. diamondb@wpunj.edu

Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists
|December 7, 2007
PubMed
Summary

Multiple sclerosis (MS) patients show slower processing speed, linked to depression and fatigue. These factors significantly impact cognitive tasks, affecting memory and verbal fluency in MS.

More Related Videos

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation (tDCS) in Multiple Sclerosis (MS)
08:18

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation (tDCS) in Multiple Sclerosis (MS)

Published on: December 26, 2015

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
04:33

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Related Experiment Videos

Last Updated: Jul 9, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation (tDCS) in Multiple Sclerosis (MS)
08:18

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation (tDCS) in Multiple Sclerosis (MS)

Published on: December 26, 2015

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
04:33

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Area of Science:

  • Neuroscience
  • Psychology

Background:

  • Multiple sclerosis (MS) frequently causes neurobehavioral issues like fatigue, depression, and cognitive dysfunction.
  • Processing speed deficits are common in MS but often confounded by accuracy, making quantification difficult.

Purpose of the Study:

  • To compare processing speed in MS patients versus healthy controls, ensuring accuracy is not a confounding factor.
  • To investigate the relationship between information processing speed and cognitive functions in MS.
  • To determine the extent to which depression and fatigue mediate these relationships.

Main Methods:

  • Study included 48 participants with confirmed multiple sclerosis.
  • Employed a sensitive measure of processing speed to avoid confounding with accuracy.
  • Analyzed correlations between processing speed, cognitive tests, and self-reported depression and fatigue levels.

Main Results:

  • Slower processing speed in MS patients correlated with increased depressed mood and fatigue.
  • Deficits in processing speed were associated with lower verbal fluency, reduced word and digit recall, and poorer visual-spatial recall.
  • Depression and physical fatigue significantly influenced the association between processing speed and effortful cognitive tasks like word recall and learning.

Conclusions:

  • This study provides a more nuanced understanding of processing speed deficits in MS by using a sensitive measure.
  • Quantified the significant mediating roles of depression and fatigue in the relationship between processing speed and cognitive performance in MS.
  • Highlights the importance of addressing depression and fatigue to potentially improve cognitive function in multiple sclerosis.