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Chitotriosidase and YKL-40 in normal and pre-eclamptic pregnancies
Riza Madazli1, Mine Kucur, Altay Gezer
1Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty, Istanbul, Turkey. madazli@superonline.com
Objective:
To compare macrophage activation in normal and pre-eclamptic pregnancies by determining YKL-40 concentration and chitotriosidase activity in maternal and cord serum.
Methods:
In this prospective case-control study samples of maternal peripheral blood and umbilical venous blood were collected from 28 pre-eclamptic and 24 normotensive pregnant women and their newborns. YKL-40 concentration and chitotriosidase activity were determined by enzyme-linked immunoassay and fluorometry, respectively.
Results:
Chitotriosidase activity in maternal and cord serum and YKL-40 concentration in cord serum were significantly higher in pre-eclamptic pregnancies (P<0.001), but there was no significant difference in maternal serum levels of YKL-40 between the case and control groups (P>0.05). There was a significant positive correlation between diastolic blood pressure and (1) chitotriosidase activity in both maternal and cord serum and (2) cord serum concentration of YKL-40 (r=0.61, r=0.84, and r=0.58, respectively).
Conclusion:
This study may be the first to demonstrate maternal and fetal macrophage activation in pre-eclampsia.
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