An enhanced miniaturized assay for antimicrobial prospecting
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Updated: Jul 9, 2026

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
Published on: April 18, 2019
Shannon M Smith1, Andrew J Beattie, Michael R Gillings
1Department of Biological Sciences, Macquarie University, NSW, Australia. smsmith@bio.mq.edu.au
Abstract:
Bioprospecting for novel antimicrobials increasingly relies on extremely small samples unsuitable for conventional bulk extraction and assay. We developed a microtitre plate assay for minimal amounts of test materials which is rapid, extremely sensitive, allows time-course analysis and reduces false negatives. Developed for the analyses of antimicrobial sensitivity and resistance, the technique is appropriate for assays where source materials are scarce.
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