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Updated: Jul 9, 2026

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Published on: August 29, 2012

[Granulomatous disease in common variable immunodeficiency].

M Malphettes¹, E Oksenhendler, L Galicier

¹Département d'immunologie clinique, hôpital Saint-Louis, 1 avenue Claude-Vellefaux, Paris, France.

La Revue De Medecine Interne

|December 7, 2007

Summary

This summary is machine-generated.

Common variable immunodeficiency (CVID) can cause granulomatous disease, mimicking sarcoidosis. Treatment involves immunoglobulin replacement, immunosuppressants, and anti-TNFalpha therapy, though management is challenging in immunocompromised patients.

Related Experiment Videos

Last Updated: Jul 9, 2026

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Published on: August 29, 2012

Area of Science:

Immunology
Primary Immunodeficiency Disorders
Granulomatous Diseases

Context:

Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by defective immunoglobulin production.
Granulomatous disease is a significant manifestation of CVID, often presenting with multi-organ involvement.
CVID-associated granulomatous disease can clinically resemble sarcoidosis, distinguished by low immunoglobulin levels.

Purpose:

To review recent advancements in understanding granulomatous disease in CVID.
To discuss current and emerging treatment strategies for granulomatous disease in CVID patients.

Summary:

Granulomatous disease in CVID involves granuloma formation in organs like lungs, lymph nodes, liver, and spleen.
Associated immunological abnormalities include lymphopenia and reduced T-cell proliferation.
Rare TNFalpha gene polymorphisms have been observed in CVID patients with granulomatous disease.

Impact:

Granulomatous disease in CVID can lead to severe complications, especially with pulmonary involvement.
Treatment strategies include immunoglobulin substitution, corticosteroids, cyclophosphamide, and anti-TNFalpha antibodies.
Managing these treatments in immunocompromised CVID patients presents significant challenges.