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Updated: Jul 9, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
Nonopioid analgesics
Muhammad A Munir1, Nasr Enany, Jun-Ming Zhang
1Department of Anesthesiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, PO Box 67031, Cincinnati, OH 45267-0531, USA. munirma@ucmail.uc.edu
Abstract:
Nonopioid analgesics represent a varied collection of analgesic agents, many of which also possess antipyretic or anti-inflammatory actions. As a group, nonopioid analgesics represent reasonable first-line analgesics for a variety of mild to moderate painful conditions and also often may be useful in conjunction with other analgesics (eg, opioids) for a myriad of severe painful conditions. Clinicians treating pain should be familiar with the actions, adverse effects, and individual agents in the group of nonopioid analgesics.
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