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Updated: Jul 9, 2026

Identification and Dissection of Diverse Mouse Adipose Depots
Published on: July 11, 2019
The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and
Takashi Kadowaki1, Toshimasa Yamauchi, Naoto Kubota
1Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. kadowaki-3im@h.u-tokyo.ac.jp
Abstract:
Adiponectin is an abundantly expressed adipokine in adipose tissue and has direct insulin sensitizing activity. A decrease in the circulating levels of adiponectin by interactions between genetic factors and environmental factors causing obesity has been shown to contribute to the development of insulin resistance, type 2 diabetes, metabolic syndrome and atherosclerosis. In addition to its insulin sensitizing actions, adiponectin has central actions in the regulation of energy homeostasis. Adiponectin enhances AMP-activated protein kinase activity in the arcuate hypothalamus via its receptor AdipoR1 to stimulate food intake and decreases energy expenditure. We propose a hypothesis on the physiological role of adiponectin: a starvation gene in the course of evolution by promoting fat storage on facing the loss of adiposity.
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