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Infection and inflammation decrease apolipoprotein M expression.

Kenneth R Feingold1, Judy K Shigenaga, Lisa G Chui

  • 1Department of Veterans Affairs Medical Center, Metabolism Section, SFVAMC, San Francisco, CA 94121, United States. kenneth.feingold@ucsf.edu

Atherosclerosis
|December 7, 2007
PubMed
Summary
This summary is machine-generated.

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Apolipoprotein M, a protein protecting against atherosclerosis, decreases during inflammation and infection. This finding links inflammatory conditions to increased cardiovascular disease risk.

Area of Science:

  • Biochemistry
  • Immunology
  • Cardiovascular Science

Background:

  • Inflammation can alter lipid metabolism, increasing atherosclerosis risk.
  • Apolipoprotein M (ApoM) is an HDL-associated protein with anti-atherosclerotic properties, primarily expressed in the liver and kidney.

Purpose of the Study:

  • To investigate the regulation of apolipoprotein M during the acute phase response to inflammation.

Main Methods:

  • Systemic inflammation was induced in mice using LPS, zymosan, or turpentine.
  • Hep3B hepatoma cells were treated with inflammatory cytokines TNF or IL-1.
  • Apolipoprotein M mRNA and serum levels were measured.
  • Human serum samples from patients with bacterial or HIV infections were analyzed.

Related Experiment Videos

Main Results:

  • Inflammatory stimuli (LPS, zymosan, turpentine) decreased hepatic and renal apolipoprotein M mRNA levels.
  • TNF and IL-1 treatment reduced apolipoprotein M mRNA in Hep3B cells.
  • Decreased mRNA correlated with reduced ApoM secretion and serum levels in mice.
  • Human patients with infections showed decreased serum apolipoprotein M levels.

Conclusions:

  • Apolipoprotein M functions as a negative acute phase reactant, decreasing during infection and inflammation.
  • The observed decrease in ApoM during inflammation is consistent with the increased risk of atherosclerosis in these conditions.