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McCune-Albright syndrome associated with acromegaly and bipolar affective disorder
Pelin Ozcan-Kara1, Babek Mahmoudian, Belkis Erbas
1Hacettepe University, Hacettepe Medical School, Department of Nuclear Medicine, 06100-Sihhiye, Ankara, Turkey.
Abstract:
McCune-Albright syndrome is a rare disorder caused by an activating mutation in the gene (GNAS1) encoding the subunit of the G protein. This syndrome is characterized by polyostotic fibrous dysplasia, café-au-lait pigmentation, and multiple endocrine hyperfunction. A 29-year-old male with polyostotic fibrous dysplasia, café-au-lait pigmentations, and pituitary adenoma is presented in this report. The patient had accompanying bipolar affective disorder, which might have been caused by the underlying genetic abnormality.
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