Related Experiment Video
Updated: Jul 9, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues
Published on: August 4, 2022
Local lymphocytic and epithelial activation in a case of autoimmune oophoritis
Anne-Sophie Bats1, Patricia Monnier Barbarino, Marie-Christine Bene
1Immunology Laboratory, Faculty of Medicine & CHU, Vandoeuvre-les-Nancy, Nancy, France.
Objective:
To further define the immunological tissular modifications in premature ovarian failure (POF).
Method:
The patient was followed up for premature ovarian failure and mild endometriosis associated with serum antiovarian antibodies. A laparoscopic ovarian biopsy was decided on to analyze the tissue and support the onset of immunosuppressive therapy. Immunohistochemistry was performed using monoclonal antibodies directed against T cell membrane markers, as well as activation molecules, to define the composition of the cellular infiltrate and the consequences on ovarian tissue.
Result(S):
A dense infiltration of activated T lymphocytes was observed in close contact with follicular epithelium expressing HLA-DR and CD40.
Conclusion(S):
This observation supports the role of cellular immunity in ovarian autoimmunity with features very similar to those reported in murine models and other human autoimmune endocrine pathologies.
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