Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Bone marrow transplantation. Preliminary results].

P Pimentel1, J M de Lacerda

  • 1Departamento de Hematologia, Hospital de Santa Maria, Lisboa.

Acta Medica Portuguesa
|December 1, 1991
PubMed
Summary

Bone marrow transplantation (BMT) shows promising results for hemopathies and solid tumors. This study highlights low transplant-related mortality and significant therapeutic effects in early-phase malignant hemopathies and aplastic anemia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex and gender disparities in patients with advanced gastroesophageal adenocarcinoma: data from the AGAMENON-SEOM registry.

ESMO open·2022
Same author

Trifluridine/Tipiracil (TAS-102) for refractory metastatic colorectal cancer in clinical practice: a feasible alternative for patients with good performance status.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2019
Same author

[Characteristics and quality of the of clinical practice guidelines in the Social Security of Health of Peru].

Semergen·2018
Same author

Ancestim (recombinant human stem cell factor, SCF) in association with filgrastim does not enhance chemotherapy and/or growth factor-induced peripheral blood progenitor cell (PBPC) mobilization in patients with a prior insufficient PBPC collection.

Bone marrow transplantation·2004
Same author

CGP 44532, a GABAB receptor agonist, is hedonically neutral and reduces cocaine-induced enhancement of reward.

Neuropharmacology·2002
Same author

Follow-up of anti-Aspergillus IgG and IgA antibodies in bone marrow transplanted patients with invasive aspergillosis.

Journal of clinical laboratory analysis·2002

Area of Science:

  • Hematology
  • Oncology
  • Transplantation Medicine

Context:

  • Bone marrow transplantation (BMT) is a critical therapeutic option for various hematologic malignancies, non-malignant hemopathies, and solid tumors.
  • Evaluating the early outcomes of a BMT program is essential for refining protocols and improving patient survival.
  • This study focuses on a cohort of patients undergoing allogeneic and autologous BMT.

Purpose:

  • To assess the preliminary outcomes, including transplant-related mortality, engraftment, and survival rates, of a newly established bone marrow transplant program.
  • To compare the efficacy and safety of allogeneic versus autologous BMT in different patient populations.
  • To determine the impact of disease phase on relapse-free survival in patients with malignant hemopathies undergoing allogeneic BMT.

Summary:

  • A total of 60 bone marrow transplants (41 allogeneic, 19 autologous) were performed between May 1989 and March 1991.
  • Transplant-related mortality was 19.4% for allografts and 10.5% for autografts.
  • Projected 22-month relapse-free survival was 81% for early-phase malignant hemopathies and 21.4% for advanced-phase (p<0.001); 22-month actuarial survival for aplastic anemia was 60%.

Impact:

  • The BMT program demonstrated low morbidity and mortality, suggesting significant therapeutic potential.
  • Early results indicate favorable outcomes for allogeneic BMT in early-stage hematologic malignancies and aplastic anemia.
  • Autografting showed a high success rate with only one patient experiencing engraftment failure.

Related Experiment Videos