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A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
Published on: November 7, 2017
Dilated cardiomyopathy during the course of hemolytic uremic syndrome
Alexandra Alexopoulou1, Spyros P Dourakis, Christos Zovoilis
12nd Department of Medicine, University of Athens Medical School, Hippokration General Hospital, Greece. alexopou@ath.forthnet.gr
Abstract:
A 47-year-old woman presented with severe hemolytic uremic syndrome (HUS) followed by heart failure. An echocardiogram showed an ejection fraction of 20%, and a cardiac catheterization followed by a myocardial histologic evaluation demonstrated dilated cardiomyopathy. Plasma exchange and hemodialysis were performed regularly. The later outcomes of renal function and cardiomyopathy were favorable. A review of the literature confirmed the rare and severe nature of cardiac lesions occurring in the course of HUS. This case indicates the importance of cardiac monitoring in HUS and the need for prolonged support.
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