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Updated: Jul 9, 2026

Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy
Published on: June 29, 2021
[Ruptured cirrhotic nodulus treated with collagen patch]
1Dr. Bugyi István Kórház Sebészeti Osztály Szentes, Sima F. u. 44-58. 6600. pappzoltandr@index.hu
Insights
A ruptured cirrhotic nodule caused life-threatening abdominal bleeding. A novel collagen patch achieved rapid hemostasis, saving the patient and demonstrating its clinical utility.
Area of Science:
- Hepatology
- Surgical Innovation
- Emergency Medicine
Background:
- Cirrhosis frequently leads to complications, including spontaneous bleeding.
- Hemorrhagic shock necessitates immediate intervention to stabilize patients.
- Identifying the source of abdominal bleeding is critical for effective treatment.
Observation:
- A 53-year-old patient with cirrhosis presented with acute abdomen and hemorrhagic shock.
- Ultrasound (UH) and CT imaging indicated abdominal bleeding of unknown origin.
- Surgical exploration revealed arterial bleeding from a ruptured cirrhotic nodule.
Findings:
- Application of Tacho-Comb, a fibrinogen/thrombin-coated collagen patch, to the liver wound.
- Immediate and effective hemostasis was achieved using the collagen patch.
- The patient experienced an uneventful recovery and was discharged.
Implications:
- Tacho-Comb offers a promising solution for controlling hepatic bleeding in cirrhotic patients.
- This case highlights the successful management of a rare but severe complication of cirrhosis.
- Minimally invasive hemostatic techniques are crucial in managing emergency surgical cases.
Abstract:
The authors review the case of a fifty-three-year-old cirrhotic patient. He was admitted to the emergency unit with symptoms of acute abdomen and haemorrhagic shock. Abdominal bleeding of unknown origin was revealed by UH and CT imaging. After circulatory resuscitation, urgent abdominal exploration was indicated. During operation arterial bleeding of a ruptured cirrhotic nodulus was found. Tacho-Comb (a human fibrinogen/thrombin coated collagen patch) was applied onto the hepatic wound. Prompt haemostasis was achieved. The patient was discharged after an uneventful postoperative period.
Related Concept Videos
Cirrhosis I: Introduction
Cirrhosis II: Pathophysiology
Healing II: Complications
Chronic Pancreatitis II: Collaborative Care
Assessment:

