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Evaluation of genetic markers linked to hemophilia A locus: an Indian experience
Atreyee Saha1, Saibal Mukherjee, Mahua Maulik
1Molecular & Human Genetics Division, Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Jadavpur, Kolkata, 700 032, India.
Abstract:
Hemophilia A is an X-linked recessive bleeding disorder caused by defects in factor VIII gene (F8). Our study examines variations of single nucleotide polymorphism (SNP) in F8 in the Indian population and establishes the utility of a combination of SNP and microsatellite markers for the successful identification of carriers in the affected families.
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