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Inflammatory cellular infiltrates in melanocytic nevi
G Benz1, D Hölzel, C Schmoeckel
1Laboratory of Dermatohistopathology, Munich, Germany.
The American Journal of Dermatopathology
|December 1, 1991
Summary
Melanocytic nevi often show lymphohistiocytic infiltrates, particularly early stages with junctional melanocyte hyperplasia. This cellular reaction may indicate antigen appearance or stromal response, not melanin increase.
Area of Science:
- Dermatopathology
- Immunohistochemistry
- Melanocytic Lesions
Background:
- Lymphohistiocytic infiltrates are common in melanocytic nevi.
- Understanding factors associated with these infiltrates is crucial for diagnosis and prognosis.
Purpose of the Study:
- To investigate the association between lymphohistiocytic infiltrates and various histological and clinical parameters in melanocytic nevi.
- To identify predictors for the presence and intensity of these infiltrates.
Main Methods:
- Histopathological examination of 1,054 melanocytic nevi.
- Semiquantitative assessment of lymphohistiocytic infiltrates.
- Statistical analysis including chi-square tests and univariate/multivariate analyses.
Main Results:
- 78% of melanocytic nevi exhibited lymphohistiocytic infiltrates.
- Infiltrates were weak (33%), moderate (50%), pronounced (16%), or very strong (1%).
- Basal layer melanocyte hyperplasia and vertical thickness in compound nevi were significantly associated with infiltrates.
Conclusions:
- Melanocytic nevi with junctional melanocyte hyperplasia often display a moderate to pronounced stromal reaction.
- This reaction may signify antigen presentation by proliferating melanocytes or a response to necrotic cells.
- The presence of infiltrates is not related to increased melanin pigment.