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Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
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Cushing Syndrome II: Pathophysiology

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Coronary Artery Disease III: Clinical Manifestations

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Related Experiment Video

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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Crowned Dens syndrome.

Shinichi Goto1, Jutaro Umehara, Toshimi Aizawa

  • 1Department of Orthopaedic Surgery, Senboku Kumiai General Hospital, 1-30 Omagari-torimati, Daisen, Akita 014-0027, Japan. cfq40980@par.odn.ne.jp

The Journal of Bone and Joint Surgery. American Volume
|December 7, 2007
PubMed
Summary

Crowned dens syndrome, characterized by severe neck pain and calcium deposits, is more common in the elderly. Combination therapy with prednisolone and NSAIDs effectively relieves symptoms.

Area of Science:

  • Rheumatology
  • Orthopedics
  • Radiology

Background:

  • Crowned dens syndrome presents with severe neck pain and calcification around the odontoid process.
  • Limited case reports highlight the unclear clinical features of this condition.

Purpose of the Study:

  • To investigate the clinical features of crowned dens syndrome.
  • To evaluate treatment outcomes for affected patients.
  • To propose diagnostic criteria for crowned dens syndrome.

Main Methods:

  • Studied 40 patients diagnosed with crowned dens syndrome via CT scans showing calcification.
  • Collected data on pain onset, inflammatory markers, and treatment responses.
  • Analyzed clinical features and diagnostic findings.

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Main Results:

  • The majority of patients were over 70 years old, with a male-to-female ratio of 0.6.
  • All patients exhibited restricted neck motion and positive inflammatory indicators.
  • Calcium deposition was prevalent around the odontoid process, particularly posteriorly.

Conclusions:

  • Crowned dens syndrome is likely underdiagnosed, especially in the elderly population.
  • Key diagnostic indicators include acute severe neck pain, restricted motion, inflammation, and calcification.
  • Combined treatment with prednisolone and nonsteroidal anti-inflammatory drugs (NSAIDs) is recommended for symptom relief.