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Published on: August 7, 2017
Persistence and remission in childhood asthma: a population-based asthma birth cohort study
Teresa To1, Andrea Gershon, Chengning Wang
1Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada. teresa.to@sickkids.on.ca
Insights
Early asthma diagnosis and healthcare use predict persistent childhood asthma. Attentive follow-up and management are crucial in the initial years to improve long-term outcomes.
Area of Science:
- Pediatric Pulmonology
- Epidemiology
- Health Services Research
Background:
- Childhood asthma is a significant public health concern with variable long-term persistence.
- Predicting asthma persistence is crucial for timely intervention and resource allocation.
Purpose of the Study:
- To examine and predict the persistence of childhood asthma.
- To identify early indicators of persistent asthma in children.
Main Methods:
- Longitudinal population-based cohort study of children diagnosed with asthma before age 6 in Ontario, Canada.
- Follow-up until age 11, defining persistent asthma based on continued asthma events.
- Logistic regression analysis to assess risks associated with early health service use.
Main Results:
- Over half of children (54.4%) had a second asthma encounter within 1 year of diagnosis.
- Children hospitalized for asthma in the first year had a 3-fold risk of persistent asthma.
- At least 4 physician visits within the first year increased persistent asthma risk by 2.6-fold.
Conclusions:
- Intensive health services use within the first year post-diagnosis is a strong predictor of persistent childhood asthma.
- Highlights the need for proactive follow-up, management, and education strategies in early childhood asthma care.
Objectives:
To examine and predict the persistence of childhood asthma.
Design:
Longitudinal population-based cohort study.
Setting:
Ontario, Canada.
Participants:
Children born in 1994 and diagnosed with asthma before age 6 years were followed up until age 11 years. Diagnosis of asthma was defined as 1 asthma hospitalization or 2 asthma physician claims within 3 years prior to age 6 years.
Main Exposure:
Intensity of health services use within 1 year postdiagnosis.
Main Outcome Measures:
Those who continued to have asthma events (hospitalization and/or physician visit) between ages 6 and 11 years were considered to have "persistent asthma," while others were in "remission." Cumulative rates of health services use for asthma during follow-up were calculated. Logistic regression analysis was used to estimate risks of persistent asthma.
Results:
The study included 34,216 children diagnosed with asthma before age 6 years. More than half (54.4%) experienced a second asthma health care encounter within 1 year after diagnosis. By age 12 years, nearly half (48.6%) were in remission. Children with asthma hospitalization during the first year postdiagnosis had a 3-fold risk of persistent asthma by age 12 years (95% confidence interval, 2.69-3.39; P < .001). Those with at least 4 physician visits also had a 2.6-fold risk of persistent asthma during follow-up (95% confidence interval, 2.34-2.81; P < .001).
Conclusion:
The concentration of health services use within 1 year following the initial diagnosis of childhood asthma points to the need for attentive follow-up and ongoing management and education strategies in the early years.
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