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Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Genomic maintenance: the p53 poly(ADP-ribosyl)ation connection

Rafael Alvarez-Gonzalez1

  • 1Department of Biomedical Sciences, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107-2699, USA. ralvarez@hsc.unt.edu

Science'S STKE : Signal Transduction Knowledge Environment
|December 7, 2007
PubMed
Summary

Genomic integrity in eukaryotes is maintained by cell cycle progression and molecular signaling. Poly(ADP-ribose) polymerase-1 (PARP-1) and p53 proteins cooperate to ensure chromosome stability through posttranslational modification.

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