Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
Assessment of the Gastrointestinal System II: Health Perception Pattern01:29

Assessment of the Gastrointestinal System II: Health Perception Pattern

Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
Assessment of the Gastrointestinal System I: Subjective Data01:17

Assessment of the Gastrointestinal System I: Subjective Data

Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems related to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The putative role of the microbiota in the development of neuropsychiatric disorders following early childhood malnutrition.

Gut microbes·2026
Same author

The role of gut microbiota in chronic intestinal pseudo-obstruction: exploring fecal microbiota transplantation as a treatment option.

Gut microbes·2026
Same author

Innate immune system signaling and intestinal dendritic cells migration to the brain underlie behavioral changes after microbial colonization in adult mice.

Brain, behavior, and immunity·2025
Same author

Molecular Mechanisms Underlying Loss of Vascular and Epithelial Integrity in Irritable Bowel Syndrome.

Gastroenterology·2024
Same author

Post-infectious ibs following Clostridioides difficile infection; role of microbiota and implications for treatment.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2024
Same author

Oral tryptophan activates duodenal aryl hydrocarbon receptor in healthy subjects: a crossover randomized controlled trial.

American journal of physiology. Gastrointestinal and liver physiology·2024

Related Experiment Video

Updated: Jul 9, 2026

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time
06:01

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time

Published on: July 26, 2024

Translating symptoms into mechanisms: functional GI disorders.

Stephen M Collins1

  • 1Intestinal Diseases Research Program, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. scollins@mcmaster.ca

Advances in Physiology Education
|December 7, 2007
PubMed
Summary

Functional gastrointestinal disorders (FGIDs) are common, causing chronic abdominal symptoms without structural issues. Their complex causes involve gut function, bacteria, and inflammation, leading to pain, bloating, and altered bowel habits.

More Related Videos

Simulating Pancreatic Neuroplasticity: In Vitro Dual-neuron Plasticity Assay
10:29

Simulating Pancreatic Neuroplasticity: In Vitro Dual-neuron Plasticity Assay

Published on: April 14, 2014

Related Experiment Videos

Last Updated: Jul 9, 2026

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time
06:01

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time

Published on: July 26, 2024

Simulating Pancreatic Neuroplasticity: In Vitro Dual-neuron Plasticity Assay
10:29

Simulating Pancreatic Neuroplasticity: In Vitro Dual-neuron Plasticity Assay

Published on: April 14, 2014

Area of Science:

  • Gastroenterology
  • Digestive Health
  • Microbiome Research

Background:

  • Functional gastrointestinal disorders (FGIDs) represent a prevalent clinical challenge in gastroenterology.
  • These conditions are characterized by chronic abdominal symptoms without identifiable structural abnormalities.
  • The etiology of FGIDs is multifactorial, encompassing behavioral, infectious, and inflammatory factors.

Purpose of the Study:

  • To elucidate the complex pathogenesis of functional gastrointestinal disorders.
  • To identify the key mechanisms contributing to common FGID symptoms.
  • To provide a comprehensive overview of current understanding in FGID research.

Main Methods:

  • Review of existing literature on FGID pathophysiology.
  • Analysis of mechanisms including motility, visceral sensitivity, and epithelial function.
  • Investigation of the role of gut microbiota and fermentation.

Main Results:

  • FGIDs present with diverse symptoms such as abdominal pain, diarrhea, constipation, and bloating.
  • Underlying mechanisms involve dysregulation of gastrointestinal motility and visceral perception.
  • Altered epithelial barrier function and gut commensal bacteria fermentation disturbances are implicated.

Conclusions:

  • Functional gastrointestinal disorders stem from a heterogeneous interplay of factors.
  • Understanding these mechanisms is crucial for effective diagnosis and management.
  • Further research into gut-brain axis and microbiome interactions is warranted.