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Related Experiment Video

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Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells

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Published on: June 5, 2015

Reversible hypogammaglobulinaemia.

I M E Desar¹, C M R Weemaes, M van Deuren

¹Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

The Netherlands Journal of Medicine

|December 7, 2007

Summary

Recovery from hypogammaglobulinaemia is rare but possible. This study highlights spontaneous immunoglobulin restoration in three patients and suggests testing antibody responses after stopping immunoglobulin substitution.

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Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

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Published on: December 3, 2019

Area of Science:

Immunology
Clinical Medicine

Background:

Hypogammaglobulinaemia, a condition of low immunoglobulin levels, often necessitates long-term immunoglobulin substitution therapy.
Understanding potential recovery mechanisms is crucial for optimizing patient management.

Observation:

Four patients requiring prolonged immunoglobulin substitution for hypogammaglobulinaemia were studied.
One patient had systemic lupus erythematosus (SLE), while three had primary hypogammaglobulinaemia of unknown etiology.
All patients exhibited IgA deficiency, persisting even after recovery of IgG and IgM production.

Findings:

Spontaneous recovery of immunoglobulin production was observed in three patients without known cause.
Cessation of azathioprine therapy might have contributed to recovery in the SLE patient.
Two patients with anti-IgA antibodies resumed producing them after discontinuing immunoglobulin therapy.

Implications:

Reversible hypogammaglobulinaemia, though uncommon, can occur.
Discontinuation of immunoglobulin substitution and assessment of vaccine response are recommended when recovery is suspected.