Comment on 'Analysis of electroencephalograms in Alzheimer's disease patients with multiscale entropy'

In the article by Escudero et al (2006), there are only random samples, which are useful for the validity of the study design. In this author's opinion, there are still other clinicophysiological characteristics that merit consideration and scrutiny as discussed below. The hypothesis set by the original authors needs to be adequately justified. Their hypothesis appears to be that the multiscale entropy (MSE) is positively related to a non-linear analysis of an electroencephalogram on patients with Alzheimer's disease.