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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...

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Related Experiment Video

Updated: Jul 9, 2026

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve
09:13

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Published on: June 14, 2017

Proteomics as a tool for biomarker discovery.

Elise C Kohn1, Nilofer Azad, Christina Annunziata

  • 1Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. kohne@mail.nih.gov

Disease Markers
|December 7, 2007
PubMed
Summary

Developing new biomarkers for early cancer detection is crucial. Advanced serum peptide and protein analysis shows promise for identifying ovarian cancer, potentially improving patient survival and quality of life.

Related Experiment Videos

Last Updated: Jul 9, 2026

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve
09:13

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Published on: June 14, 2017

Area of Science:

  • Biomarker discovery
  • Proteomics
  • Bioinformatics

Background:

  • Current cancer biomarkers often lack sensitivity, specificity, or clinical utility.
  • Early-stage ovarian cancer diagnosis is challenging due to non-specific symptoms, leading to late-stage detection in most women.
  • There is a critical need for accurate biomarkers to enable early intervention and improve patient outcomes.

Purpose of the Study:

  • To explore novel technologies for identifying and validating new disease biomarkers.
  • To highlight the potential of serum peptide and protein analysis for early cancer diagnosis.
  • To emphasize the need for validation of new biomarkers in ovarian cancer.

Main Methods:

  • Utilizing advanced mass spectrometry techniques for serum peptide and protein analysis.
  • Applying sophisticated bioinformatics approaches to identify biomarker signatures.
  • Reviewing the criteria for reliable and clinically useful biomarkers.

Main Results:

  • Proteomic analysis combined with bioinformatics has generated promising biomarker signatures.
  • These signatures can discriminate between cancer presence and unaffected individuals in preliminary studies.
  • The identified biomarkers hold potential for early diagnosis and intervention.

Conclusions:

  • Novel technologies offer powerful tools for biomarker discovery and validation.
  • Serum peptide and protein analysis represents a promising avenue for early ovarian cancer detection.
  • Further validation and outcome studies are essential to establish the clinical value of these biomarkers for improved survival and quality of life.