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Updated: Jul 9, 2026

Comparative Lesions Analysis Through a Targeted Sequencing Approach
Published on: November 5, 2019
Epilog: comparative medicine, one medicine and genomic pathology
1Department of Pathology and Laboratory Medicine, Center for Comparative Medicine, University of California, Davis, CA 95616, USA. rdcardiff@ucdavis.edu
Abstract:
The study of breast cancer has involved comparative pathology since the 1890s. Molecular biology has allowed the detailed examination of human, mouse, and rat genomes. The genes that are associated with breast cancer in humans cause cancer in genetically modified mice and rats. Global genomic analyses demonstrate even broader genomic homologies. The pathology illustrates the principle of One Medicine. This issue examines these contributions and opens the way for the examination of other mammalian species. The development of a new discipline, Genomic Pathology, can now be anticipated.
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