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Updated: Jul 9, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
[Parathyroid and bone. Bone metabolism in hypoparathyroidism]
1Teikyo University Chiba Medical Center, Third Department of Medicine.
Abstract:
Hypoparathyoidism is classified into two categories: PTH deficient and PTH refractory (i.e. pseudohypoparathyrodism [PHP]). Bone metabolism is different between the two. In PTH deficient hypoparathyroidism such as post-operative hypoparathyroidism, BMD is increased with relatively low bone turnover markers. In PHP, which characterized by PTH resistance in proximal renal tubules, bone response to PTH is sometimes preserved. In some PHP cases, high bone turnover state is observed, which correlates with serum PTH levels.
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