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Updated: Jul 9, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
[Parathyroid and bone. Indication for parathyroidectomy in primary hyperparathyroidisms]
1Osaka City University Graduate School of Medicine, Department of Metabolism, Endocrinology and Molecular Medicine.
Abstract:
Primary hyperparathyroidism is a disease in which somatic chromosomal defects such as activations of oncogenes or inactivations of tumor suppressor genes enhance chromosomal parathyroid cell growth. Decreased calcium-sensing receptor causes oversecretion of PTH from abnormal parathyroid cells. Oversecreted PTH enhances bone turnover and finally exhibits bone fragility. In this review, the indications of parathyroidectomy and the effects of parathyroidectomy on bone in primary hyperparathyroidism are discussed.
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