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Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Related Experiment Video

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A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
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Ionized magnesium and gestational age.

Rajeev Mehta1, Anna Petrova

  • 1Department of Pediatrics, Division of Neonatal Medicine, Robert Wood Johnson Medical School-UMDNJ, New Brunswick, New Jersey, USA. mehtara@umdnj.edu

Indian Journal of Pediatrics
|December 7, 2007
PubMed
Summary
This summary is machine-generated.

Extremely preterm infants have higher ionized magnesium (IMg) levels, linked to lower pH. This association, even without magnesium tocolysis, requires consideration for preventing potential hypermagnesemia-related pathology in neonates.

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Area of Science:

  • Neonatal physiology
  • Perinatal medicine
  • Electrolyte balance

Background:

  • Magnesium (Mg) homeostasis is crucial for preterm neonates at risk of brain pathology.
  • Data on ionized Mg and gestational age (GA) in newborns are conflicting.

Purpose of the Study:

  • To investigate the association between ionized magnesium (IMg) and gestational age (GA) in preterm neonates.
  • To assess Mg homeostasis in relation to pH and ionized calcium (ICa) in early neonatal life.

Main Methods:

  • Measured total and ionized magnesium (TMg, IMg) and calcium (TCa, ICa), and pH in cord blood and on day 2 of life.
  • Studied 22 neonates across different gestational ages (<32, 32-34, ≥35 weeks) without magnesium tocolysis.
  • Analyzed correlations between IMg, GA, pH, and ICa.

Main Results:

  • Ionized magnesium (IMg) fraction was significantly higher in very preterm infants (GA < 32 weeks) compared to those with GA ≥ 35 weeks.
  • Higher IMg levels correlated with lower cord blood pH (r=-0.80, p<0.0001) and lower ICa (r=-0.52, P<0.01).
  • Multiple regression showed IMg levels significantly associated with decreased pH, but not GA or ICa.

Conclusions:

  • Extremely preterm infants are at risk for elevated ionized magnesium (IMg) associated with lower pH, even without magnesium tocolysis.
  • This finding necessitates careful monitoring to prevent hypermagnesemia-related pathology in this vulnerable population.
  • Understanding Mg shifts in preterm neonates is vital for optimizing clinical management and outcomes.