Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...

Psychological and Sociocultural Causes of Schizophrenia

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...

Biological Causes of Schizophrenia

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sodium-Glucose Cotransporter 2 Inhibitors and Dementia Risk in Patients With Psychiatric Disorders.

JAMA network open·2026

Same author

Impaired Hippocampal Circuitry and Memory Dysfunction in Schizophrenia.

Nature. Mental health·2026

Same author

High prevalence of CNS-directed autoantibodies in patients with schizophrenia.

bioRxiv : the preprint server for biology·2026

Same author

Brain Health from Sleep EEG: A Multicohort, Deep Learning Biomarker for Cognition, Disease, and Mortality.

NEJM AI·2026

Same author

Sleep and wake markers of thalamocortical functioning in early-course psychosis and first-degree relatives.

Schizophrenia (Heidelberg, Germany)·2026

Same author

With No Surprises From the EMERGENT-4 Trial, Where Do We Go From Here?

The American journal of psychiatry·2026

Search research articles

Related Experiment Video

Updated: Jul 9, 2026

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

The relation between antisaccade errors, fixation stability and prosaccade errors in schizophrenia.

Jason J S Barton¹, Manisha Pandita, Katy Thakkar

¹Department of Neurology, University of British Columbia, Vancouver, BC, Canada. jasonbarton@shaw.ca

Experimental Brain Research

|December 7, 2007

Summary

This summary is machine-generated.

Schizophrenia patients struggle with inhibitory control, leading to more antisaccade errors. This difficulty in suppressing unwanted eye movements, not novel response generation, contributes to these errors.

More Related Videos

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity

Published on: March 18, 2019

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

Related Experiment Videos

Last Updated: Jul 9, 2026

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity

Published on: March 18, 2019

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

Area of Science:

Neuroscience
Psychiatry
Ophthalmology

Background:

Antisaccade errors in schizophrenia are debated, possibly stemming from impaired saccadic inhibition or novel response generation.
Understanding the precise nature of these errors is crucial for diagnosing and treating schizophrenia-related cognitive deficits.

Purpose of the Study:

To investigate if antisaccade errors in schizophrenia are linked to difficulties in inhibiting saccades during fixation.
To differentiate between impaired saccadic inhibition and novel response generation as causes of antisaccade errors.

Main Methods:

Ocular motor data from 15 schizophrenia patients and 16 healthy controls were analyzed.
Fixation stability was assessed during saccadic trials (pre-target onset) and separate fixation trials.
Correlations between fixation instability, antisaccade error rates, and prosaccade error rates were examined.

Main Results:

Schizophrenia subjects exhibited higher fixation loss rates than controls.
Antisaccade error rates positively correlated with fixation instability during the preparatory period of saccadic trials.
Antisaccade errors were more frequent during unstable fixation and correlated with prosaccade error rates.

Conclusions:

Antisaccade errors in schizophrenia are associated with impaired inhibitory control within the saccadic system.
The correlation between antisaccade and prosaccade errors suggests a broader deficit in goal-oriented behavior, not solely impaired inhibition of automatic prosaccades.