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Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Antidepressant Drugs: MAOIs and Other Agents

Antidepressant Drugs: MAOIs and Other Agents

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Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Depression: Overview

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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

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Updated: Jul 9, 2026

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Published on: May 22, 2026

Managing depression in geriatric populations.

¹Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA. beyer001@mc.duke.edu

Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists

|December 7, 2007

Summary

This summary is machine-generated.

Late life depression is a significant public health issue in the US. Research shows it

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Last Updated: Jul 9, 2026

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Published on: May 22, 2026

Area of Science:

Gerontology
Psychiatry
Public Health

Background:

Late-life depression is a growing public health concern.
The elderly population in the US is rapidly expanding.
Recent research has significantly advanced understanding of this condition.

Purpose of the Study:

To review current understanding of late-life depression.
To discuss implications for treatment and prevention strategies.
To identify future research directions.

Main Methods:

Systematic review of published studies.
Focus on the past decade of research.
Analysis of epidemiology, phenomenology, comorbidity, and treatment.

Main Results:

Prevalence and presentation of depression vary with age in older adults.
Late-life depression is highly prevalent and poses risks to physical health, social support, and functioning.
Etiology and treatment response show heterogeneity among older adults, differing from younger populations.

Conclusions:

Current understanding of late-life depression is reviewed.
Implications for effective treatment and prevention are discussed.
Key research questions and future considerations are outlined.