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Related Concept Videos

Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Activation of Integrins01:15

Activation of Integrins

Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding events provide an effective stimulus.
Integrins01:10

Integrins

Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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Updated: Jul 9, 2026

A Flow Cytometry-Based High-Throughput Technique for Screening Integrin-Inhibitory Drugs
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A Flow Cytometry-Based High-Throughput Technique for Screening Integrin-Inhibitory Drugs

Published on: February 2, 2024

beta1 integrin as a molecular therapeutic target.

Nils Cordes1, Catherine C Park

  • 1OncoRay - Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany. Nils.Cordes@Oncoray.de

International Journal of Radiation Biology
|December 7, 2007
PubMed
Summary

Beta1 integrins play a key role in cancer cell survival after radiation therapy. Targeting beta1 integrins may improve radiation therapy efficacy by acting as radiosensitizers.

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Area of Science:

  • Oncology
  • Cell Biology
  • Radiotherapy Research

Background:

  • Radiation therapy (RT) is a cornerstone of cancer treatment but faces challenges from dose-limiting toxicities and treatment resistance.
  • The tumor microenvironment, including the cell-extracellular matrix (ECM), significantly influences cancer response to therapy.
  • Beta1 integrins are increasingly recognized for their role in cancer progression, metastasis, and resistance to treatments.

Purpose of the Study:

  • To review emerging findings on the role of beta1 integrins in mediating cancer cell survival following radiation exposure.
  • To explore the potential of targeting beta1 integrins as a strategy to enhance the effectiveness of radiation therapy.

Main Methods:

  • This mini-review synthesizes recent scientific literature and research findings.
  • The focus is on studies investigating the signaling pathways of beta1 integrins post-irradiation (IR).

Main Results:

  • Beta1 integrins are implicated in mediating crucial survival signals after radiation.
  • These survival signals are transmitted through both canonical and non-canonical integrin signaling pathways.
  • Beta1 integrins are identified as promising therapeutic targets for overcoming radiation resistance in solid tumors.

Conclusions:

  • Emerging evidence highlights the critical role of beta1 integrins in cancer cell survival after radiation.
  • Inhibitory agents targeting beta1 integrins show significant promise as radiosensitizers to improve RT efficacy.