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Published on: July 5, 2017
Flavonoids and ent-labdane diterpenoids from Andrographis paniculata and their antiplatelet aggregatory and
Tian-Shung Wu1, Huei-Jen Chern, Amooru Gangaiah Damu
1Department of Chemistry, National Cheng Kung University, Tainan, Taiwan. tswu@mail.ncku.edu.tw
Abstract:
Two new flavones, designated as andropaniculosin A (1) and andropaniculoside A (2), and 30 known compounds were isolated as a result of detailed chemical examination on the whole plants of Andrographis paniculata. Their structures have been elucidated mainly by 1D and 2D NMR, and MS spectroscopic methods. Among them, four flavonoids showed potent inhibition of collagen, arachidonic acid, thrombin, and platelet activation factor induced platelet aggregation. Furthermore, a diterpenoid demonstrated moderate vasorelaxing effect in isolated rat thoracic aorta.
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