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Persistence on treatment and blood pressure control with different first-line antihypertensive treatments: a

Maria Grazia Prandin1, Arrigo F G Cicero, Maddalena Veronesi

  • 1D. Campanacci Clinical Medicine and Applied Biotechnology Department, Alma Mater Studiorum, University of Bologna, Italy.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|December 7, 2007
PubMed

Insights

Angiotensin receptor blockers (ARBs) and ACE inhibitors showed higher treatment persistence in hypertensive patients compared to other drug classes. Lercanidipine also improved persistence among calcium channel blockers.

Area of Science:

  • Cardiology
  • Pharmacology
  • Hypertension Management

Background:

  • Hypertension treatment adherence is crucial for long-term cardiovascular health.
  • Comparing first-line antihypertensive drug classes is essential for optimizing patient outcomes.

Purpose of the Study:

  • To evaluate treatment persistence and blood pressure reduction across different first-line antihypertensive drug classes.
  • To compare the efficacy of specific agents within drug classes, such as lercanidipine versus other calcium channel blockers.

Main Methods:

  • A 24-month follow-up study involving 347 hypertensive patients.
  • Random allocation to various first-line antihypertensive treatments.
  • Analysis of treatment persistence rates and blood pressure changes.

Main Results:

  • Higher persistence was observed with Angiotensin Receptor Blockers (ARBs) (68.5%) and ACE inhibitors (64.5%) compared to CCBs (51.6%), beta-blockers (44.8%), and diuretics (34.4%).
  • Lercanidipine demonstrated superior persistence (59.3%) versus other CCBs (46.6%).
  • Greater blood pressure reduction was achieved with ARBs (-11.2/-5.8 mmHg), ACE inhibitors (-10.5/-5.1 mmHg), and CCBs (-8.5/-4.6 mmHg) than with beta-blockers (-4.0/-2.3 mmHg) and diuretics (-2.3/-2.1 mmHg).

Conclusions:

  • ARBs and ACE inhibitors are associated with superior treatment persistence in hypertension management.
  • Lercanidipine offers improved persistence within the CCB class.
  • These findings support the use of ARBs and ACE inhibitors for better adherence and blood pressure control in hypertensive patients.

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