New analogs of acyclovir substituted at the side chain
Zofia Jahnz-Wechmann1, Jerzy Boryski, Kunisuke Izawa
1Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Nucleosides, Nucleotides & Nucleic Acids
|December 7, 2007
Abstract:
A series of novel analogs of acyclovir, substituted with an alkyl (methyl, ethyl, n-butyl) or phenyl group at the positions 1', 4', and/or 5', has been obtained in a direct one-pot coupling reaction of guanosine and the respective 1,3-dioxolanes. The new acyclonucleosides were essentially inactive in antiviral (HSV, VV, VSV, HBV) evaluation in vitro.
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