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Updated: Jul 9, 2026

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
Published on: June 26, 2020
Thermodynamic studies on PNA and PNA/DNA dendrimer formation
Maria Moccia1, Domenica Musumeci, Margherita Valente
1Dipartimento di Scienze Biologiche sez. Biostrutture, Università degli Studi di Napoli Federico II, Napoli, Italy.
Abstract:
In this work we report a kinetic and thermodynamic study relative to the formation of gel systems based on PNA and PNA/DNA dendrimers, useful for drug delivery or diagnostic applications. We realized two kinds of systems: a PNA-based monomolecular system formed by an autoassembling PNA tridendron (A) and a PNA/DNA bimolecular system based on a PNA tridendron with a mixed sequence and a DNA crosslinker (B). Both systems have the ability to form a three-dimensional network by means of specific W-C base pairing.
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