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Reduced TGF-beta1 expression and its target genes in human insulinomas

A Nabokikh1, A Ilhan, M Bilban

  • 11Department of Medicine III, Medical University of Vienna, Austria.

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [And] German Diabetes Association
|December 7, 2007
PubMed
Summary

Transforming growth factor beta 1 (TGF-beta1) signaling is reduced in human insulinomas, impacting cell growth. This down-regulation, despite increased TGF-beta receptor II, suggests a novel pathway in pancreatic tumor development.

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