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Related Concept Videos

Transduction01:16

Transduction

Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome are...
Evolution of Microbial Genome01:08

Evolution of Microbial Genome

Microbial genome evolution is a highly dynamic process shaped by continual gene gain and loss across species and strains. This genomic flexibility allows microorganisms to adapt rapidly to environmental pressures and interactions with other organisms. Central to understanding this diversity is the distinction between the core and pan genomes.The core genome comprises the genes shared by all sampled strains of a species, representing essential functions needed for fundamental cellular processes.
Translation in Prokaryotes01:29

Translation in Prokaryotes

Prokaryote translation is a complex, highly coordinated process that converts genetic information from mRNA into functional proteins. It involves three stages: initiation, elongation, and termination, each facilitated by specific molecular components.Initiation of TranslationThe process begins with the assembly of the ribosomal subunits and initiation factors on the mRNA. In bacteria, the 30S ribosomal subunit recognizes the Shine-Dalgarno sequence in the mRNA, a conserved region upstream of...
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...

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Related Experiment Video

Updated: Jul 9, 2026

Determination of the Optimal Chromosomal Location(s) for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach
11:12

Determination of the Optimal Chromosomal Location(s) for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach

Published on: September 11, 2017

Ectopic gene conversions in bacterial genomes.

Robert T Morris1, Guy Drouin

  • 1Département de biologie et Centre de recherche avancée en génomique environnementale, Université d'Ottawa, 30 Marie Curie, Ottawa, ON K1N 6N5, Canada.

Genome
|December 7, 2007
PubMed
Summary

Pathogenic bacteria exhibit increased gene conversion rates, allowing for greater genetic diversity. This higher recombination permissiveness in pathogens may be an adaptive strategy for evolution.

Area of Science:

  • Microbial genomics
  • Evolutionary biology
  • Bacterial genetics

Background:

  • Gene conversion is a mechanism of genetic recombination.
  • Understanding recombination in bacterial pathogens is crucial for evolutionary and medical insights.

Purpose of the Study:

  • To characterize gene conversions in bacterial genomes across different species groups.
  • To investigate the relationship between gene conversion, multigene family size, and pathogenicity.
  • To compare recombination patterns in pathogenic versus nonpathogenic bacteria.

Main Methods:

  • Analysis of gene conversions in 75 bacterial genomes from five species groups.
  • Correlation analysis between gene conversion frequency, multigene family size, and pathogenicity.
  • Comparison of conversion length with flanking sequence similarity.

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Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
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Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

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Detection of Horizontal Gene Transfer Mediated by Natural Conjugative Plasmids in E. coli
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Detection of Horizontal Gene Transfer Mediated by Natural Conjugative Plasmids in E. coli

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Last Updated: Jul 9, 2026

Determination of the Optimal Chromosomal Location(s) for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach
11:12

Determination of the Optimal Chromosomal Location(s) for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach

Published on: September 11, 2017

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
14:06

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

Published on: November 12, 2012

Detection of Horizontal Gene Transfer Mediated by Natural Conjugative Plasmids in E. coli
06:56

Detection of Horizontal Gene Transfer Mediated by Natural Conjugative Plasmids in E. coli

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Main Results:

  • Gene conversion frequency positively correlates with multigene family size.
  • Gene conversion occurs twice as frequently in pathogenic species compared to nonpathogenic ones.
  • Pathogenic bacteria show a reduced correlation between conversion length and sequence similarity, indicating higher permissiveness.

Conclusions:

  • Pathogenic bacteria exhibit a higher rate of gene conversion, likely an adaptive trait.
  • Increased recombination permissiveness in pathogens facilitates greater genetic variability and adaptation.
  • Findings align with previous studies on *E. coli* and suggest broader implications for bacterial evolution.