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Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...

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Related Experiment Video

Updated: Jul 9, 2026

Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution
08:41

Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution

Published on: August 16, 2012

Endoscopic optical coherence tomography based on a microelectromechanical mirror.

Y Pan, H Xie, G K Fedder

    Optics Letters
    |December 7, 2007
    PubMed
    Summary
    This summary is machine-generated.

    A novel endoscopic optical coherence tomography (OCT) system uses a microelectromechanical mirror for lateral scanning, enabling real-time imaging of biological tissues during endoscopy.

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    Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

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    Area of Science:

    • Biomedical Engineering
    • Medical Imaging
    • Optical Science

    Background:

    • Endoscopic procedures require high-resolution imaging for diagnosis and treatment.
    • Existing endoscopic imaging modalities have limitations in resolution and real-time cross-sectional visualization.
    • Optical Coherence Tomography (OCT) offers non-invasive, high-resolution cross-sectional imaging.

    Purpose of the Study:

    • To develop and describe a novel endoscopic optical coherence tomography (OCT) system.
    • To enable real-time, cross-sectional imaging of biological tissues within the gastrointestinal tract.
    • To demonstrate the system's capability for tissue thickness measurement and in-vivo imaging.

    Main Methods:

    • Development of an endoscopic OCT system incorporating a microelectromechanical (MEMS) mirror for lateral light scanning.
    • Adaptation of a front-view OCT probe to fit the instrument channel of a standard endoscopic sheath.
    • Integration of OCT imaging with direct endoscopic visual guidance for real-time feedback.

    Main Results:

    • The endoscopic OCT system achieved transverse and axial resolutions of approximately 20 µm and 10.2 µm, respectively.
    • High-resolution cross-sectional images (500x1000 pixels) covering a 2.9 mm x 2.8 mm area were acquired at approximately 5 frames/s.
    • The system demonstrated a dynamic range of nearly 100 dB, crucial for imaging through scattering biological tissues.
    • Successful demonstration of thickness measurements and bladder tissue imaging in preliminary applications.

    Conclusions:

    • The developed endoscopic OCT system provides real-time, high-resolution cross-sectional imaging capabilities.
    • The MEMS-based lateral scanning mechanism facilitates efficient and precise imaging during endoscopic procedures.
    • This technology holds significant potential for advancing diagnostic and interventional capabilities in various medical fields, including urology and gastroenterology.