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Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Updated: May 30, 2026

Orthotopic Hind Limb Transplantation in the Mouse

Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

Every allograft needs a silver lining.

Alan G Contreras¹, David M Briscoe

¹Transplantation Research Center and Division of Nephrology, Children's Hospital Boston, Boston, Massachusetts 02115, USA.

The Journal of Clinical Investigation

|December 7, 2007

Summary

This summary is machine-generated.

Chronic allograft rejection may stem from microvascular damage preceding tissue fibrosis. Protecting blood vessels after transplantation could be key to long-term organ survival.

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Last Updated: May 30, 2026

Orthotopic Hind Limb Transplantation in the Mouse

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Published on: February 12, 2016

Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research

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Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation

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Published on: June 13, 2025

Area of Science:

Transplantation immunology
Vascular biology
Fibrosis research

Background:

Chronic allograft rejection is a major cause of organ transplant failure.
Current hypotheses suggest cumulative tissue injury leads to fibrosis.
The precise sequence of events initiating rejection remains debated.

Purpose of the Study:

To investigate the early events in alloimmune-mediated rejection.
To determine if microvascular damage precedes tissue fibrosis in tracheal allografts.
To explore potential therapeutic targets for improving allograft survival.

Main Methods:

Murine orthotopic tracheal allograft model.
Alloimmune response assessment.
Histopathological analysis of graft tissues.

Main Results:

Alloimmune-mediated microvascular loss was observed.
This vascular damage preceded significant tissue damage and fibrosis.
Findings challenge the traditional view of rejection initiation.

Conclusions:

Microvascular injury is an early event in allograft rejection.
Maintaining vascular integrity may be crucial for preventing fibrosis.
Early vascular repair could enhance long-term allograft survival, particularly in lung transplants.