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Apoptosis

Apoptosis

Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...

Adult Stem Cells

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...

Negative Regulator Molecules

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.

Covalently Linked Protein Regulators

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....

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Updated: Jan 30, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Apoptosis in cutaneous melanomas.

Mariana Costache¹, Olga Simionescu, Maria Sajin

¹Department of Pathology, Victor Babes National Institute for Pathology and Biomedical Sciences, Bucharest, Romania. m_costache_dermatopat@yahoo.com

Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie

|December 7, 2007

Summary

This summary is machine-generated.

This study quantifies apoptotic cell death in cutaneous melanoma tissues using the TUNEL technique. Findings help understand melanoma progression and improve patient outcomes for this rising cancer.

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Last Updated: Jan 30, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

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Published on: March 8, 2022

Activation of Apoptosis by Cytoplasmic Microinjection of Cytochrome c

Activation of Apoptosis by Cytoplasmic Microinjection of Cytochrome c

Published on: June 29, 2011

Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function

Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function

Published on: December 8, 2010

Area of Science:

Oncology
Immunology
Cell Biology

Background:

Cutaneous melanoma incidence is rising globally.
Despite early diagnosis, advanced lesions contribute to increased mortality.
Melanoma's unique immunologic development warrants further investigation.

Purpose of the Study:

To quantify apoptotic cell death in cutaneous melanoma.
To utilize the in situ end-labeling (TUNEL) technique for single-cell analysis.
To investigate the role of apoptosis in melanoma progression.

Main Methods:

Employed the in situ end-labeling (TUNEL) technique.
Analyzed 30 cases of cutaneous melanoma tissues.
Quantified apoptotic cell death at the single-cell level.

Main Results:

Successfully detected and quantified apoptosis in melanoma tissues.
Provided single-cell level data on apoptotic cell death.
Established a method for assessing apoptosis in melanoma.

Conclusions:

Apoptosis detection is feasible in cutaneous melanoma using TUNEL.
Quantifying apoptosis offers insights into melanoma biology.
Further research can link apoptosis levels to clinical outcomes.