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Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

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Related Experiment Video

Updated: Jul 9, 2026

An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C

An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C

Published on: June 1, 2018

DNA methylation in mouse embryonic stem cells and development.

Tom Latham¹, Nick Gilbert, Bernard Ramsahoye

¹Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

Cell and Tissue Research

|December 7, 2007

Summary

Mammalian development relies on DNA methylation, but failures occur when it

Area of Science:

Epigenetics
Developmental Biology
Genomics

Background:

Mammalian development involves significant global DNA methylation changes during genomic reprogramming.
Normal DNA methylation is critical for successful development.
Deficiencies in DNA methylation lead to developmental failure, though underlying reasons are not fully understood.

Purpose of the Study:

To review the roles of DNA methyltransferases in mammalian development.
To explore the significance of active DNA demethylation in early development.

Main Methods:

Literature review of DNA methyltransferases and demethylation mechanisms.
Discussion of existing research on DNA methylation's role in development.

Main Results:

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Oct4GiP Reporter Assay to Study Genes that Regulate Mouse Embryonic Stem Cell Maintenance and Self-renewal

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Last Updated: Jul 9, 2026

An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C

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Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina

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DNA methyltransferases (DNMTs) are key enzymes in establishing and maintaining DNA methylation patterns.
Active DNA demethylation processes are crucial but less understood in early development.
The precise mechanisms causing developmental failure due to DNA methylation deficiency require further investigation.

Conclusions:

Understanding DNA methyltransferases and demethylation is essential for comprehending developmental processes.
Further research is needed to elucidate the full significance of DNA methylation dynamics in development and the consequences of its disruption.