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Updated: Jul 9, 2026

Robotic-assisted Left Pneumonectomy For Vanishing Lung Syndrome
Published on: January 23, 2026
[Unusual cause of pneumomediastinum]
W Faber1, A Hirner, M Kaminski
1Klinik und Poliklinik für Allgemein-, Viszeral-, Thorax- und Gefässchirurgie, Medizinische Fakultät der Rheinischen Friedrich-Wilhelms-Universität, Sigmund-Freud-Strasse 25, Bonn, Germany. wlfaber@gmx.net
Abstract:
The 3,4-methylenedioxy-N-methylamphetamine (MDMA) also known as ecstasy is a hallucinogen prevalently used by teenagers. Known complications of its consumption are hyperpyrexia, disseminated intravasal coagulation, acute kidney failure, and rhabdomyolysis. We report about an 18-year-old patient who developed a pneumomediastinum and skin emphysema by excluded lesions of the lung and respiratory tract. We present the hypothesis of the pathogenesis of this disease. The correct therapy is observation of the patient and maximum sedation.
Insights
Ecstasy (MDMA) use can lead to severe complications. This case highlights rare pneumomediastinum and skin emphysema in an adolescent, suggesting a need for careful observation and sedation.
Area of Science:
- Toxicology
- Emergency Medicine
- Pulmonology
Background:
- 3,4-methylenedioxy-N-methylamphetamine (MDMA), or ecstasy, is a recreational hallucinogen frequently used by adolescents.
- Known MDMA complications include hyperpyrexia, disseminated intravascular coagulation, acute kidney failure, and rhabdomyolysis.
Observation:
- An 18-year-old patient presented with pneumomediastinum and skin emphysema.
- These conditions were associated with excluded lesions of the lung and respiratory tract.
Findings:
- The case suggests a potential, albeit rare, link between MDMA consumption and the development of pneumomediastinum and skin emphysema.
- A hypothesis for the pathogenesis of this specific complication is presented.
Implications:
- This case underscores the diverse and potentially severe systemic effects of MDMA beyond typical toxicities.
- Management involves patient observation and maximal sedation, highlighting the need for supportive care in managing rare MDMA-induced complications.
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