Related Experiment Video
Updated: Jul 9, 2026

Cell Subtype-specific Analysis of Neuronal Membrane Proteasome in Somatosensory Neurons
Published on: October 10, 2025
Severe sensorimotor neuropathy after intake of highest dosages of vitamin B6
Hans-Jürgen Gdynia1, Timo Müller, Anne-Dorte Sperfeld
1Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany. hans-juergen.gdynia@uni-ulm.de
Abstract:
We illustrate a white caucasian patient with a severe sensorimotor neuropathy due to vitamin B6 hypervitaminosis. The patient used the pendulum to calculate his daily metabolic demands and ingested 9.6g pyridoxine/day. To our knowledge, this is the highest dosage of vitamin B6 administered to humans over prolonged periods of time ever reported in the medical literature. The unique aspect of this case is the muscle weakness and motor findings on electrophysiological testing in what is suggested by the literature to be a pure sensory neuronopathy.
Related Concept Videos
Vitamins
Drug toxicity: Idiosyncratic Reactions
Drug Toxicity: Dose-Dependent Reactions
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Drug Toxicity: Risk factors
Drug Toxicity: Allergic Reactions