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Cecal Ligation and Puncture-induced Sepsis as a Model To Study Autophagy in Mice
Published on: February 9, 2014
Autonomic dysfunction in experimental sepsis induced by cecal ligation and puncture
João Alexandre Trés Pancoto1, Pollyanna Barbosa Farias Corrêa, Gabriela Ravanelli Oliveira-Pelegrin
1Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Brazil.
Autonomic Neuroscience : Basic & Clinical
|December 7, 2007
Summary
Experimental sepsis impairs autonomic control, reducing baroreflex sensitivity and altering cardiovascular function. This autonomic dysfunction may contribute to hormonal changes seen in severe sepsis.
Area of Science:
- Physiology
- Pathophysiology
- Cardiovascular Research
Background:
- Sepsis involves systemic inflammation and refractory hypotension, progressing to severe sepsis.
- Understanding sepsis-induced cardiovascular and hormonal changes is critical for treatment.
Purpose of the Study:
- To evaluate hormonal and cardiovascular alterations in experimental sepsis.
- To investigate the impact of sepsis on autonomic nervous system control.
Main Methods:
- Cecal ligation and puncture (CLP) model in male Wistar rats.
- Measurements included mean arterial pressure, heart rate, plasma vasopressin, and baroreflex sensitivity.
- Analysis of heart rate and mean arterial pressure variability.
Main Results:
- Sepsis induced hypotension and increased heart rate.
- Plasma vasopressin levels initially increased then returned to basal levels.
- Baroreflex sensitivity and autonomic variability were significantly reduced post-CLP.
Conclusions:
- Polymicrobial sepsis impairs autonomic control of the heart and vessels.
- Reduced autonomic activity contributes to baroreflex impairment.
- Autonomic dysfunction may influence vasopressin levels in late-stage sepsis.
