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Updated: Jun 17, 2026

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
Published on: March 22, 2017
Esophageal dysmotility in patients who have eosinophilic esophagitis
1Center for Motility and Functional Gastrointestinal Disorders, Children's Hospital Boston, Hunnewell - Ground, 300 Longwood Avenue, Boston, MA 02115, USA. samuel.nurko@childrens.harvard.edu <samuel.nurko@childrens.harvard.edu>
Abstract:
The understanding of esophageal motility alterations in patients who have eosinophilic esophagitis (EE) is in its infancy despite the common presenting complaint of dysphagia. A diversity of motility disorders has been reported in patients who have EE including achalasia, diffuse esophageal spasm, nutcracker esophagus, and nonspecific motility alterations including high-amplitude esophageal body contractions, tertiary contractions, abnormalities in lower esophageal sphincter pressure, and other peristaltic problems. Some evidence suggests that treatment of EE will improve motility. Technological advances such as high-resolution manometry and combined manometry with impedance may provide new insight into more subtle motility abnormalities.
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