Expression, regulation and function of trail in atherosclerosis

Area of Science:

• Cardiovascular Biology
• Immunology
• Cellular Biology

Background:

• Atherosclerosis involves plaque buildup in arteries due to VSMCs, inflammatory cells, and lipids.
• The tumor necrosis factor (TNF) family significantly influences atherosclerosis progression.
• TNF-related apoptosis-inducing ligand (TRAIL) is detected in atherosclerotic tissues, suggesting a role.

Purpose of the Study:

• To review the expression, regulation, and function of TRAIL.
• To summarize evidence linking TRAIL to the development of atherosclerosis.
• To highlight novel functions of TRAIL in vascular cells.

Main Methods:

• Literature review of studies on TRAIL expression and function.
• Analysis of data implicating TRAIL in atherosclerotic processes.
• Examination of TRAIL's role in vascular cell migration, proliferation, and tone.

Main Results:

• TRAIL is present in both normal and atherosclerotic vascular tissue.
• TRAIL promotes endothelial cell (EC) and VSMC migration and proliferation.
• TRAIL influences vascular tone and immune regulation.

Conclusions:

• TRAIL plays a multifaceted role in the development and progression of atherosclerosis.
• Understanding TRAIL's functions offers potential therapeutic targets for atherosclerosis.
• Further research is warranted to fully elucidate TRAIL's contribution to vascular disease.